Sign Out
Contraindicated in patient with: Hypersensitivity to the active substance or to any of the excipients.
Congestive heart failure (NYHA II-IV).
Increased risk of cardiovascular disease (Ischaemic heart disease and stroke).
Peripheral arterial disease, and/or cerebrovascular disease (including patients who have recently undergone coronary artery bypass graft surgery or angioplasty).
Patients with hypertension whose blood pressure has not been adequately controlled.
Pregnancy.
Active peptic ulceration or active gastro-intestinal (GI) bleeding.
Severe hepatic dysfunction (serum albumin <25 g/l or Child-Pugh score ≥10).
Estimated renal creatinine clearance <30 ml/min.
Children and adolescents under 16 years of age.
Inflammatory bowel disease.
